In particular, there may not be a simple increase or decrease in neural response or behavioral performance, but a capacity to adjust neural processing and behavioral performance Protosappanin-B during a task to most efficaciously match the environmental demands. There are three main findings in this study. First, elite warfighters relative to comparison subjects showed relatively greater right-sided insula, but attenuated left-sided insula, activation. Second, these individuals showed selectively greater activation to angry target faces relative to fearful or happy target faces bilaterally in the insula. Third, these individuals also showed slower response latencies to fearful and happy target faces. Taken together, these findings support the notion that elite warfighters, when examined cross-sectionally, deploy greater neural processing resources toward potential threat-related facial expressions and reduced processing resources to non-threat-related facial expressions. This finding suggests that rather than expending more effort in general, elite warfighters show more focused neural and performance tuning, such that greater neural processing resources are directed toward threat stimuli and processing resources are conserved when facing a nonthreat stimulus situation. Moreover, the suggestion of relatively greater right-sided 3-n-Butylphathlide insula activation is consistent with the lateralization of feelings hypothesis, which suggests that right-sided processing is a more energy-consuming condition. Individualswhoarelikelyto complete this training program are characterized by an attitude of mental toughness, achievement motivation, physical strength, physical endurance, emotional stability, and team orientation. These factors are clearly multidimensional but support the critical importance of optimal monitoring and balancing of the relationship between brain processing and body functioning. These factors are reminiscent of Damasio��s somatic marker model, which extends the James Lang theory of emotion, and involves the insular cortex that can instantiate body sensation without necessarily receiving peripheral inputs.