The dermal papilla is believed to be the control center that regulates the size of the hair follicle, and may also be the main regulator of the hair cycle. The outer root sheath contains a variety of cell-types that are especially important in the regeneration of the epidermis after injury. Since the first report of a link between the SOD1 mutations and FALS, more than 130 different mutations have been reported. Two leading hypotheses have been advanced to Eupalinilide-C explain the apparent ����toxic gain of function���� of the mutant SOD1 protein. The first of these, the ����aggregation toxicity���� hypothesis, suggests that mutant SOD1 becomes misfolded and oligomerized to form intracellular aggregates, which then diminish the availability of essential proteins for normal cellular function. The second hypothesis, the ����oxidative damage���� theory, conjectures that toxicity is caused by the aberrant chemistry of the metal-binding sites of the mutant SOD1, such as peroxidase or superoxide-reducing activities and peroxynitrite catalysis. These hypotheses, however, are unable to explain the multiple perturbations of cellular function identified in FALS, including excessive excitatory toxicity, protein misfolding, impaired energy production, abnormal calcium metabolism, altered axonal transport, activation of proteases and nucleases, and so on. There are four other means converting biomass to hydrogen: 1) direct polysaccharide gasification; 2) direct glucose chemical catalysis after polysaccharide hydrolysis; 3) anaerobic fermentations ; and 4) polysaccharide- or glucose-ethanol fermentations followed by ethanol chemical reforming. The chemical Lucidenic-acid-LM1 methods have low hydrogen yields due to poor selectivity of catalysts and requires high reaction temperatures. Anaerobic hydrogen fermentation is well known for its low hydrogen yield of 4 H2/glucose. The combination of ethanol fermentation and ethanol-to-hydrogen reforming has a theoretical yield of 10 H2/glucose unit. Allowing 5,10% fermentation loss and,5% reforming loss, the practical hydrogen yield through ethanol could be ca. 75% of the maximum yield. Assembly of the high-substrate-selectivity enzymes results in an artificial cascade enzymatic pathway, accompanied by a high hydrogen yield, three time higher than the theoretical yield from biological hydrogen fermentations and much higher than those from chemical catalysis. We improve the method first described by Woodward by starting with a less costly and abundant substrate�Cstarch.