However, the ejection fraction did not differ between the groups. The link between myocardial lipids and systolic function is of interest, since myocardial lipid accumulation has been linked to the development of diabetic cardiomyopathy triggered 
by lipotoxicity. Until now, our knowledge mainly relies on animal data, and recent reports have focused on the quality rather than the quantity of myocardial lipids; there is evidence that in particular saturated free fatty acids might favor the development of cardiac hypertrophy and dysfunction, while unsaturated free fatty acids might play a protective role. Hence, it can be speculated that the assessment of lipid composition rather than quantification of triglycerides in the heart alone, might help to draw a link between myocardial lipid accumulation and cardiac dysfunction. In our current study, we found that besides blood pressure, myocardial wall thickness was tightly associated with BMI, glycemic control, hyperinsulinemia and hsCRP. Again, we think that long-term exposure to these co-existing risk factors might accelerate the development of myocardial hypertrophy in patients with diabetes. In contrast to myocardial lipids, hepatic steatosis, estimated by the Fatty Liver Index, was tightly correlated with metabolic parameters: glycemic control, hyperinsulinemia as well as dyslipidemia. In a recent study in women with prior gestational diabetes, hepatic lipid content was doubled in pGDM compared to healthy controls and tightly associated with insulin resistance. Thus, we conclude that hepatic lipid accumulation better Ganoderic-acid-F reflects glucometabolic alterations than do myocardial lipids. This could be explained by a higher turnover of the myocardial lipid pool compared to that of the liver. There are some study limitations that have to be addressed. First of all, the study group is rather small in terms of participants, due to the difficulty of recruitment from the long-lasting project with a well-characterized cohort and the cost- and time-consuming examinations. Secondly, we investigated a quite young, premenopausal female population, whose cardiovascular risk factors might still be low to detect relevant changes. Furthermore, diastolic function is only described by the E/A-ratio, which might limit our conclusions on diastolic function. Breast cancer is the most common malignancy among women in the United States, among which 70% of them are ER+. The selective ER modulator tamoxifen has shown great success in the treatment of ER+ breast cancer. However, over 40% ER+ patients with advanced disease fail to respond to tamoxifen effectively, even for those who responded at the beginning would develop acquired resistance eventually. Approximately 25% of all women diagnosed with breast cancer die from their disease despite having been treated according to state-of-the-art clinical guidelines. In the meantime, adjuvant systemic therapy saves a significant number of lives, however, many patients are subjected to unnecessary adjuvant therapies with the potential of causing more harm than good. The present lack of criteria to help Echinacoside individualize breast cancer treatment indicates the need for a novel way to predict prognosis and therapy response.