The UPBEAT-UK research programme was set up in 2007 and consists of qualitative and quantitative studies to determine the prevalence of depression and anxiety in primary care patients with CHD, to explore the relationship between these diagnoses and continued cardiac symptoms, new cardiac morbidity and mortality. At its core is a cohort study of 803 patients recruited from primary care CHD registers in 16 practices in South London. Participants are followed up every six months for up to four years so that relationships between changes in physical and mental health can be tracked thus furthering our knowledge of the ORM-3819 direction of causality. Also as part of this programme of research a pilot randomised controlled trial to improve depression outcomes for primary care patients with depression and CHD is also underway. The aims of this research were to describe the sociodemographic and clinical characteristics of the recruited population with CHD and determine the prevalence rate of depression and factors associated with depression in this population. Historical cardiac variables were not associated with current diagnoses of depression, but there was a strong association with currently reporting chest pain. Depression can be seen to be more common in women and in ethnic minority participants and the prevalence reduced with age. Significant associations were:DM-NOFD being divorced or separated, living alone, being unable to carry out usual daily activities and being in pain or discomfort. Being disabled in more than 1 domains of the EQ-5D showed an OR of 7.5 for depression. Reported problems in all domains of the SPQ were also strongly associated with depression. To our knowledge, this is the first study to measure the prevalence of depression in a primary care population with CHD. The CHD register was shown to be an efficient means to access a community population with documented CHD; only 4% did not have this pathology but had other cardiac conditions. The majority had been diagnosed with CHD for many years and thus provided a picture of older patients living at home with CHD. However our cohort consisted of only 27% of those on the registers and this should be born in mind when interpreting our result.