Recently, emerging evidence has indicated an association between OPG/RANK/ RANKL gene polymorphisms with carcinogenesis. Several studies demonstrated additional loci to be associated with breast cancer including the chromosomal region 8q24 for OPG gene. SNP rs3102735 of the OPG gene has been reported to be associated with the susceptibility of breast cancer in Caucasian population. Similarly,ABT-263 a genetic variant near the 59-end of RANK was associated with a breast cancer risk. The mechanism underlying the association remains obscure so far. Yet, vast majority of the association on chromosome 8q24 lies at approximately 128 Mb and is related to various tumor entities in addition to breast cancer, including prostate and colon cancer. In conclusion, our study provides with the evidence that functional polymorphism of RANK rs1805034 T.C is associated with the susceptibility of ESCC. We acknowledge there are several limitations in this study that need to be addressed. First of all, the study subjects were all recruited from several local medical centers within same area, which may not completely represent the general Chinese population, especially when diverse regional environmental factors exist. Secondly,ALK5 Inhibitor II the detailed information regarding cancer metastasis and survival were not provided as the follow-up study is still ongoing, which hinders further analyses of the impact of these SNP polymorphisms on the ESCC progression and prognosis. Lastly, as the epidemiologic complexities of esophageal cancer are vast, rendering screening and prevention limited at best. The association between nutrition factors, exposure to fungal toxins or N-nitroso-compound in food and risk of ESCC is not studied. Further studies among different regions or ethnic populations with diverse nutrition conditions, and supplemented with functional analyses, are warranted to verify our findings. Multiple myeloma is a malignant neoplasm of bone marrow plasma cells, representing the second most common hematologic malignancy worldwide.