Therefore, in as much as prior insights into the structure of the ribosomes and their components at high resolution leaves no question that the overall architecture of the translational machinery of the cell has been strongly conserved in all kingdoms, it is worth noting that inter-kingdom differences among ribosomal components may inevitably exist, even though the functional significance of these structural variations has not been clarified yet. Overall, our findings of several eukaryotic homologs of T.cruzi ribosomal P protein acidic termini provide a window to suggest that cross reaction of antibodies against C-terminal Epimedin-C sequences of several animal, plant and protozoal ribosomal P proteins with heart tissue possibly mediates EMF in a similar manner as C- termini of T. cruzi do for Changas disease. It is, nevertheless, equally still likely that the mechanisms of molecular mimicry between prior suspected EMF-insults and myocardial tissue are mediated via different myocardial antigensthereby, beta-Sitosterol making the specified protein-portions in our study not the likely cause of EMF. We postulate that metabolic uptake may be such one candidate route of exposure to consider. The possibility that metabolic uptake of the still undefined insult plays a role in the aetiology of EMF arises in light of earlier work that had speculated that metabolites of plantain ingestion may be the cause of EMF. In a latter controlled study of thirty Nigerians with established endomyocardial fibrosis, however, Ojo found that no significant increase in serum 5hydroxytryptamine levels occurred in these patients after plantain ingestion. This finding underlined the difference between endomyocardial fibrosis and carcinoid heart disease by proving that no correlation exists between the incidence of endomyocardial fibrosis and the high content of 5-hydroxytryptamine in the local dietary staples. Our search for alternate such possible related chemical species, nevertheless, failed to yield any matching chemical species. There is hence need to conduct metabolome wide association studies to ascertain what metabolites are common among persons with EMF or EMF preceded hypereosinophilia.