In addition, Ptgs2 is also responsible for the synthesis of inflammation-related PG, and the inhibition of PG and NO production has been proposed as a JZL184 therapeutic target for inflammatory diseases, also referred to as inflammatory cytokines, are key regulators of inflammation, and the excessive production of these molecules has been associated with disease progression and severe inflammation pathologies, reported that ccl2 plays a crucial role in neuro inflammatory diseases and is also considered as a target in the treatment of neuro inflammatory disorders. Ccl2 and ccl7 are highly expressed during MS in microglia, astrocytes and other inflammatory cells.. The expression of the CXC chemokine ligand 10, cxcl10, is observed during infectious and inflammatory diseases, playing a crucial role in T-cell mediated inflammation in the CNS. In addition, Cxcl10 plays a role in inflammatory demyelinating diseases, such as MS, through the destruction of the myelin sheath or neurons by facilitating leukocyte trafficking in the brain. A previous study reported that rabies virus infection up-modulated the expression of interferon-stimulated genes inNT2-N cells. In the present study, we established the T0070907 profound up-regulation of some ISGs, in microglial cells at 2 and 4 h after LPS stimulation. This result suggested that LPS infection caused the activation of IFN-signaling-pathway-induced gene expression in BV-2 microglial cells, although the modulation of IFN-��/? genes was not detected in the RNA-Seq analysis. Furthermore, to evaluate the influence of microglial cells on A��42-induced AD we measured the expressions of selected inflammatory genes upon exposure to A��42 for 2 hand 4h time points in both BV-2 microglial and primary microglial cells. Interestingly, we found that most of the inflammatory response related genes were significantly up-regulated in primary microglial cells at the 2 and 4h time points. However, BV-2 cell lines with these factors did not induce the expression of such inflammatory response-related genes. Another hallmark of inflammation is the increased expression of TFs.