Cr2O3 in both leather samples is sufficient and similar. Therefore, the longer storage time of hide has had no observable influence on this leather quality index. Of course, the most reliable estimation of the suitability of hide preserved for longer times under vacuum for processing can only be made following industrial trials. Therefore, the hide samples preserved by vacuum and stored for 5 and 19 days were processed under industrial conditions in the ”Kedainiu oda” tannery into shoe upper leather. The leather samples produced were tested and qualitative indexes were determined. The values obtained for the main properties showed that, in both cases, high quality leather was produced. The strength properties entirely satisfied the requirements for this type of leather. Industrial trials confirmed the results obtained under laboratory conditions: after longer storage periods, hide bound a higher amount of chromium compounds during chroming and had higher thermostability compared with hide stored for shorter periods. The content of soluble Diatrizoic acid matter in dichloromethane was sufficient and similar for both leathers. Vacuum can be used for the short-term preservation of hide. It allows prolongation of the storage time without hide tissue putrefaction of up to 21 days when the storage temperature is 4uC. The number of microorganisms during that time does not reach the level of 206106 per g of hide. The microorganisms for all storage times are active but this activity is weak and has no observable influence on the quality of the hide. The decrease in hide shrinkage temperature is negligible, which shows that breakage of intermolecular bonds does not occur during the mentioned storage times. FTIR spectroscopy and DSC analysis did not show any serious structural changes, which can influence the quality of the leather produced from vacuumed hide in the future. Negligible changes in FTIR spectrum and in DSC curves of the hide samples stored for three weeks are indicative of pressing of the hide tissue and closing up of the collagen fibres. The duration of hide storage under vacuum at low temperature has an influence on the level of collagen proteins removed during processing of hide into wet blue. The amount of removed collagen proteins following 21 days of storage during liming, delimingbating and pickling processes was about 1.5-times higher than that from salted hide. Despite this, leather produced from hide stored for 19 days bound more chromium compounds and had a higher shrinkage temperature. Properties of the leather produced under industrial conditions also conformed to the requirements of shoe upper leather. The results obtained allow the conclusion that hide under vacuum at low temperature can be stored for 21 days, and this does not lower the quality of the leather produced. The management of pain, sedation and delirium has a significant impact on patients’ clinical and functional long-term outcome. Delirium affects up to 82% of the critically ill patients and is associated with long-term cognitive impairment and a 3-fold increase of 6-month mortality. Studies revealed that intensive care unit delirium is underrecognized by intensivists and nurses in daily routine care. Using a validated assessment tool significantly improves the ability of physicians and 
nurses to identify ICU delirium. Sedation practice predicts long-term mortality in critically ill patients and requires monitoring to define adequate targets and control the effect of Ginsenoside-F5 applied sedatives. Pain is the major stressor for critically ill patients and chronic pain is a severe complication that was reported by 44% of patients 6 months to 1 year after ICU discharge. Assessment for pain in mechanically ventilated patients is independently associated with improved outcome.